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Complications of Intracranial Multimodal Monitoring for Neurocritical Care


  • Intracranial multimodality monitoring (iMMM) has been implemented in multiple neurocritical care units. However, concerns could be raised about iMMM invasiveness considering the limited evidence about its clinical significance and safety profile.

  • To provide a synthesis of current evidence regarding intracranial multimodal monitoring (iMMM) complications and putative risk factors delineating its safety profile.

  • We performed a systematic review and meta-analysis (PROSPERO: CRD42021225951) according to the PRISMA and PRESS guidelines to retrieve evidence from studies reporting the use of iMMM in humans and mentioning related complications. We assessed the risk of bias using the Newcastle-Ottawa Scale and a funnel plot. The primary outcomes were iMMM complications. The secondary outcomes were practice variations as putative risk factors.

  • • Project type: SR/MA

    • Initiator: Sami Barrit, MD

    • Team status: recruiting

    • Co-investigators: Salim El Hadwe, MD, MSc; Mejdedinne Al Barajrarji, MD; Alexandre Niset, MD

    • Project status: complete

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